서울대학교 자연과학대학 해양학과 학사 (부전공 화학)
서울대학교 자연과학대학 해양학과 석사 (해양화학)
University of California-San Diego, Scripps Institution of Oceanography 박사 (해양천연물화학)
2013 – 2025
서울대학교 천연물과학연구소 소장
2012 – 2017
Howard Hughes Medical Institute International Early Career Scientist
2009 – 현재
서울대학교 약학대학 제약학과 조교수, 부교수, 교수
Instructor in Harvard Medical School, Harvard University
– Metabologenomics-based logical natural product discovery
– Structure elucidation of new natural products
– Natural product chemical biology
– Bioinformatic analysis of biosynthetic genes for natural products
– Drug discovery based on microbial natural products
1. “Configurational assignments of type-I polyketide synthases (PKSs)-derived natural products based on spectroscopic and chemical analysis: Methodologies and case studies” Cui, J.; Hilman, P. F.; Kim, G. J.; Bui, T. T. M.; Moon, K.*; Nam, S.-J.*; Choi, H.*; Oh, D.-C.* Natural Product Reports, 2025, published online.
2. “Arenicolide family macrolides provide a new therapeutic lead combating multidrug-resistant tuberculosis” Hwang, S.; Heo, B. E.; Nguyen, T. Q.; Kim, Y. J.; Lee, S.-G.; Huynh, T.-H.; Kim, E.; Jo, S.-I.; Baek, M.-J.; Shin, E.-K.; Oh, J.; Park, C.; Yoon, Y. J.; Park, E.-J.; Kim, K. T.; Ryoo, S.; Lee, D.-G.; Wood, C.; Woo, M.; Kim, D.-D.; Paik, S.*; Jo, E.-K.*; Jang, J.*; Oh, D.-C.* Angewandte Chemie International Edition, 2025, 64, e202412994.
3. “Discovery of spirosnuolides A-D, type I/III hybrid polyketide spiro-macrolides for a chemotherapeutic lead against lung cancer” Huynh, T.-H.; Jang, S. C.; Ban, Y. H.; Lee, E.-Y.; Kim, T.; Kang, I.; An, J. S.; Kang, S.; Han, J.; Kwon, Y.; Oh, D.; Park, H.-g.; Cho, J.-C.; Jang, J.; Oh, K.-B.; Nam, S.-J.; Lee, S. K.*; Oh, D.-C.* JACS Au, 2024, 4, 4821-4832.
4. “Discovery of terminal oxazole-bearing natural products by a targeted metabologenomic approach” Park, J.; Shin, Y.-H.; Hwang, S.; Kim, J.; Moon, D. H.; Kang, I.; Ko, Y.-J.; Chung, B.; Nam, H.; Kim, S.; Moon, K.; Oh, K.-B.; Cho, J.-C.; Lee, S. K.; Oh, D.-C.* Angewandte Chemie International Edition, 2024, 63, e202402465.
5. “Exploring the diverse landscape of biaryl-containing peptides generated by cytochrome P450 macrocyclases” Nam, H.; An, J. S.; Lee, J.; Lee, H.; Park, H.; Oh, K.-B.; Oh, D.-C.*; Kim, S.* Journal of the American Chemical Society, 2023, 145, 22047-22057.
6. “Targeted and logical discovery of piperazic acid-bearing natural products based on genomic and spectroscopic signatures” Shin, D.; Byun, W.
S.; Kang, S.; Kang, I.; Bae, E. S.; An, J. S.; Im, J. H.; Park, J.; Kim, E.; Ko, K.; Hwang, S.; Lee, H.; Kwon, Y.; Ko, Y.-J.; Hong, S.; Nam, S.-J.; Kim, S. B.; Fenical, W.; Yoon, Y. J.; Cho, J.-C.; Lee, S. K.*; Oh, D.-C.* Journal of the American Chemical Society, 2023, 145, 19676-19690.
7. “Discovery and biosynthesis of cihunamides, macrocyclic antibacterial RiPPs with a unique C-N linkage formed by CYP450 catalysis” An, J. S.; Lee, H.; Kim, H.; Woo, S.; Nam, H.; Lee, J.; Lee, J. Y.; Nam, S.-J.; Lee, S. K.; Oh, K.-B.; Kim, S.*; Oh, D.-C.* Angewandte Chemie International Edition, 2023, 62, e202300998.
8. “Genomic and spectroscopic signature-based discovery of natural macrolactams” Shin, Y.-H.; Im, J. H.; Kang, I.; Kim, E.; Jang, S. C.; Cho, E.; Shin, D.; Hwang, S.; Du, Y. E.; Huynh, T.-H.; Ko, K.; Ko, Y.-J.; Nam, S.-J.; Awakawa, T.; Lee, J.; Hong, S.; Abe, I.; Moore, B. S.; Fenical, W.; Yoon, Y. J.; Cho, J.-C.; Lee, S. K.; Oh, K.-B.; Oh, D.-C.* Journal of the American Chemical Society, 2023, 145, 1886-1896.
9. “Unprecedented noncanonical features of the nonlinear nonribosomal peptide synthetase assembly line for WS9326A biosynthesis” Kim, M.-S.; Bae, M.; Jung, Y.-E.; Kim, J. M.; Hwang, S.; Song, M. C.; Ban, Y. H.; Bae, E. S.; Hong, S.; Lee, S. K.; Cha, S.-S.*; Oh, D.-C.*; Yoon, Y. J.* Angewandte Chemie International Edition, 2021, 60, 19766-19773.
10. “Rhizolutin, a novel 7/10/6-tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer’s disease” Kwon, Y.; Shin, J.; Nam, K.; An, J. S.; Yang, S.-H.; Hong, S.-H.; Bae, M.; Moon, K.; Cho, Y.; Woo, J.; Park, K.; Kim, K.; Shin, J.; Kim, B.-Y.; Kim, Y.*; Oh, D.-C.* Angewandte Chemie International Edition, 2020, 59, 22994-22998.
