– 대사질환 조절 및 염증 조절 천연물 유래 화합물 발굴
– 천연물유래 신규 이차대사산물 발굴
This lab focuses on the discovery of pharmacologically active natural products using bioactivity-guided separation from domestic and foreign plant materials. Two main target s are proprotein convertase subtilisin/kexin type 9 (PCSK9) and inflammasomes. Using PCSK9 target, we are interested in discovering PCSK9 synthesis inhibitors or PCSK9-LDLR binding inhibitors which may give potential therapeutic effects in lowering cholesterol levels in blood. By using screening method based on inflammasome-mediated inflammation, we aim to find out naturally occurring molecules which may relieve or treat the symptoms of inflammatory bowel diseases.
1. Prenylated flavonoids from the roots and rhizomes of Sophora tonkinensis and their effects on the expression of inflammatory mediators and proprotein convertase subtilisin/kexin type 9. J Nat Prod, 2019, 82, 309-317
2. Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network. Sci Rep, 2018, 8, 6737
3. Chemical constituents with proprotein convertase subtilisin/kexin type 9 mRNA expression inhibitory activity from dried immature Morus alba fruits. J Agric Food Chem, 2017, 65, 5316-5321
4. SKI3301, a purified herbal extract from Sophora tonkinensis, inhibited airway inflammation and bronchospasm in allergic asthma animal models in vivo. J Ethnopharmacol, 2017, 206, 298-305
5. Isoliquiritigenin ameliorates dextran sulphate sodium-induced colitis through the inhibition of MAPK pathway. Int Immunopharmacol, 2016, 31, 223-232
